Table 11.
In silico the pharmacokinetics properties of the two pyrazole Schiff bases (8a and 9b) and the reference drugs:-.
| Schiff Basesand the Reference. |
GI Absorption |
BBB Permeant |
P-gp Substrate |
CYP1A2 Inhibitor |
CYP2C19 Inhibitor |
CYP2C9 Inhibitor |
CYP2D6 Inhibitor |
CYP3A4 Inhibitor |
Log Kp (cm/s) |
|---|---|---|---|---|---|---|---|---|---|
| 8a | High | No | No | No | Yes | Yes | No | Yes | −5.95 |
| 9b | Low | No | No | No | Yes | Yes | Yes | Yes | −5.81 |
| Norfloxacin | High | No | Yes | No | No | No | No | No | −8.98 |
| Ciprofloxacin | High | No | Yes | No | No | No | No | No | −9.09 |
| Trimethoprim | High | No | Yes | No | No | No | No | No | −7.42 |