Skip to main content
. 2020 Jun 6;25(11):2649. doi: 10.3390/molecules25112649

Figure 14.

Figure 14

Schematic design of the dual-decorated liposomes (PTX/HA-R6H4-L) for tumor-targeted drug delivery. R6H4 is a cell penetrating peptide. PTX: paclitaxel, SPC: Soy phosphatidylcholine and Chol: Cholesterol A—Degradation of HA by HAase. B—Disassembly of PTX/HA-R6H4-L to PTX/R6H4-L. C—Tumor pH-induced PTX/R6H4-L for enhanced cell penetration. a—Intravenous injection of liposomes. b—Accumulation of liposomes at the tumor site through passive and active targeting. c—Degradation of HA by HAase together with the exposure of R6H4 at HAase-rich tumor milieu. d—pH-Response of R6H4 to mildly acidic tumor microenvironment for improved cellular uptake. e—Internalization of liposomes into the tumor cells. f—Endosomal/lysosomal escape. g—Cytoplasmic release. From [102].