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. 2020 May 29;25(11):2545. doi: 10.3390/molecules25112545

Scheme 1.

Scheme 1

N-alkylaminoferrocene-(NAAF) based anticancer prodrugs targeting mitochondria due to a covalently attached carrier moiety X+. Intermediates 1, 2, 3, p-quinone methide and CO2 as well as the drug are formed from the prodrug in the medium containing high amounts of reactive oxygen species (reactive oxygen species (ROS), e.g., in cancer cells).