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Docking of compound 4 with VEGFR-2 (PDB code: 3U6J) and c-Met (PDB code: 3LQ8) (Most dual-target VEGFR/c-Met inhibitors can be divided into four parts: A, B, C and D. Part A: The main structural skeleton, mainly nitrogen-containing heterocycles. Part B: Substituted benzene ring; Part C: Meet the ‘5-atom regulations’. Part D; Benzene ring).
