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. 2020 Jun 8;25(11):2666. doi: 10.3390/molecules25112666

Figure 14.

Figure 14

General structural formula of dual-target VEGFR/c-Met kinase inhibitors (Most dual-target VEGFR/c-Met inhibitors can be divided into four parts: A, B, C and D. Part A: The main structural skeleton, mainly nitrogen-containing heterocycles. Part B: Benzene ring or substituted benzene ring; Part C: Usually meet the ‘5-atom regulations’. Part D; Mostly benzene ring, substituted benzene ring or substituted pyridine ring).