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. 2020 Jun 11;25(11):2718. doi: 10.3390/molecules25112718

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Absolute quantification of major clinically relevant human hepatic drug-metabolizing enzymes (a) and transporters (b). Protein expression levels are presented as means with standard deviations. CYP: cytochromes P450; UGT: uridine 5′-diphospho-glucuronosyltransferase; CES: carboxylesterase; P-gp, P-glycoprotein; BCRP, breast cancer resistance protein; BSEP: bile salt efflux pump; OATP: organic anion transporting polypeptide; NTCP: Na+-taurocholate co-transporting polypeptide; MCT: monocarboxylate transporter; OCT: organic cation transporter; CNT: concentrative nucleoside transporter; OAT: organic anion transporter; MRP: multidrug resistance-associated protein; MDR: multiple drug resistance; MATE: multidrug and toxin extrusion; γ-GTP: gamma glutamyl transpeptidase.