Table 1.

Comparisons of the performance of selective reaction monitoring (SRM), parallel reaction monitoring (PRM), data-dependent acquisition (DDA), and data-independent acquisition (DIA)^a.

Techniques	Performance
	Sensitivity	Specificity	Reproducibility	Multiplexing	Assay development	Prevalence in DMET studyb
SRM	+ + +	+ + +	+ + + +	+	+	+ + + +
PRM	+ + + +	+ + + +	+ + + +	+	+ +	+ +
DDA	+	+	+	+ + + +	+ + + +	+
DIA	+ +	+ +	+ +	+ + + +	+ + +	+

^aThe number of “+” indicates the performance of a specific technique with “+ + + +” denoted to the best performance and “+” for the lowest performance. ^b The prevalence of each technique used in drug-metabolizing enzymes and transporters (DMET) proteomics research was estimated from the literature collected by the writing of this paper (May, 2020).