Table 2.

Differences in DMET abundance across species and cell lines.

DMET	Tissue	Main Results	Year of Publication	Reference
CYPs, UGTs, CESs	Liver	Significant lower expression levels of major clinically-relevant DMEs were observed in the microsomes of HepG2, Hep3B, and Huh7 cell lines relative to human liver samples.	2018	[30]
BCRP, BSEP	Liver	The abundance of BCRP/Bcrp and BSEP/Bsep in the livers and isolated hepatocytes from different species (dog, rat, monkey, and human) were characterized.	2009	[54]
Transporters	Liver, Kidney	The differences in the abundance of four efflux transporters, including MDR1/P-gp, BCRP/Bcrp, MRP2/Mrp2, and MRP3/Mrp3, in the liver and kidney between different species (dog, rat, monkey, and human) were characterized.	2016	[55]
Transporters	BBB	Significant differences in protein expression levels of major drug transporters were identified between human and rodent BBB.	2011	[46]
Transporters	BBB	The protein expression levels of major drug transporters differed significantly among human cerebral microvascular endothelial cell line (hCMEC/D3), human brain microvessels, and human umbilical vein endothelial cells (HUVECs).	2012	[53]
Transporters	blood-retinal barrier	Transporters were differentially expressed between ARPE19 and hfRPE cells, the commonly used cellular models for human RPE.	2017	[56]

DME: drug-metabolizing enzyme; BBB: blood-brain barrier; CYP, cytochrome P450; UGP, uridine-diphosphate glucuronosyl transferase; CES, carboxylesterases; BCRP, breast cancer resistance protein; BSEP, bile salt efflux pump.