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. 2020 Jun 9;25(11):2687. doi: 10.3390/molecules25112687

Table 2.

In vitro cytotoxicity of Cyperus articulatus rhizome essential oil (EO).

Cell Lines Histological Type IC50 (95% CI) in µg/mL
EO DOX 5-FU
Cancer cells
HepG2 Human hepatocellular carcinoma 28.5
(23.8–36.4)
0.03
(0.01–0.2)
0.2
(0.1–0.4)
HCT116 Human colon carcinoma >50 0.1
(0.1–0.2)
0.5
(0.3–1.1)
MCF-7 Human breast adenocarcinoma 36.7
(26.7–50.5)
0.3
(0.2–0.4)
1.8
(0.7–2.3)
HL-60 Human promyelocytic leukemia 33.51
(27.3–41.2)
0.04
(0.02–0.08)
1.6
(1.2–2.2)
B16-F10 Mouse melanoma 39.7
(32.1–49.0)
0.2
(0.2–0.2)
0.5
(0.3–0.8)
Non-cancerous cell
MRC-5 Human lung fibroblast 46.0
(39.6–53.6)
0.2
(0.1–0.5)
7.5
(5.2–11.0)

The data are presented as IC50 values, in μg/mL, with their respective 95% confidence interval (95% CI) obtained by nonlinear regression from three independent experiments carried out in duplicate, as measured by the Alamar blue assay after 72 h of incubation. Doxorubicin (DOX) and 5-fluorouracil (5-FU) were used as positive controls.

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