Table 2.
Clinical trials with SiRNA-loaded vectors.
| Name | Type | Target | Type of Cancer | Status | Reference |
|---|---|---|---|---|---|
| CALAA-01 | Cyclodextrin polymer-based NPs | RRM2 | Solid tumors | Completed | NCT00689065 [83] |
| Atu027 | Liposomes | Protein kinase N3 | Solid tumors, pancreatic carcinoma | Completed Completed Completed |
NCT00938574 [84] NCT00938574 [85] NCT01808638 [86] |
| ALN-VSP | Lipid-based NPs | VEGF and KSP | Solid tumors | Completed Completed |
NCT00882180 [87] NCT01158079 [88] |
| DCR-PHXC-101 | Lipid-based NPs | Myc | Solid tumors, multiple myeloma, non-Hodgkin’s lymphoma | Terminated | NCT02110563 [89] |
| SiRNA-EphA2 | Liposomes | EphA2 | Advanced cancers | Recruiting | NCT01591356 [90] |
| siG12D LODER | Biodegradable polymeric matrix | KRASG12D | Pancreatic ductal adenocarcinoma, pancreatic cancer | Recruiting | NCT01676259 [91] |