Table 1.
α-Glucosidase inhibitory activities of the extracts and the fractions from Agrimonia pilosa L.
| Extract/Fraction | IC50 (µg/mL) |
Fr. | IC50 (µg/mL) |
Sub-Fr. | IC50 (µg/mL) |
Sub-Fr. | IC50 (µg/mL) |
|---|---|---|---|---|---|---|---|
| Methanol | 47.7 ± 3.2 | F1 | 330 ± 0.2 | F5-1 | 15.5 ± 1.6 | F5-2-1 | 51.0 ± 6.1 |
| Hexane | 60.7 ± 4.1 | F2 | 62.3 ± 2.4 | F5-2 | 4.0 ± 2.6 | F5-2-2 | 28.5 ± 2.6 |
| Ethyl acetate | 18.8 ± 2.5 | F3 | 51.3 ± 3.3 | F5-3 | 46.3 ± 3.6 | F5-2-3 | 7.5 ± 3.6 |
| n-Buthanol | 29.8 ± 2.7 | F4 | 23.3 ± 0.9 | F5-4 | >100 | F5-2-4 | 13.3 ± 4.6 |
| F5 | 19.2 ± 8.4 | F5-5 | >100 | F5-2-5 | >100 | ||
| F6 | 34.9 ± 6.1 | F5-6 | 87.5 ± 6.6 | F5-2-6 | >100 | ||
| F7 | 70.0 ± 1.8 | F5-7 | 96.9 ± 7.6 | F5-2-7 | >100 | ||
| F8 | 67.0 ± 6.4 | F5-8 | >100 | - | - | ||
| F9 | 70.5 ± 2.6 | F5-9 | >100 | - | - | ||
| - | - | F5-10 | 97.1 ± 10.6 | - | - | ||
| - | - | F5-11 | 61.3 ± 6.4 | - | - |
All extracts were examined in a set of experiments repeated three times. IC50 values of compounds represent the concentration that caused 50% enzyme activity loss.