Figure 1.

The four major modalities of cryoEM.

From left to right. A model of the HeLa cell nuclear periphery by Cryo-ET (Reprint from Ref. [24] with permission from AAAS). Model of COVID-19 spike protein by SPA (Reprint from Ref. [25] with permission from AAAS). The structure of bacteriorhodopsin determined by electron crystallography (Reprint from Ref. [21]). The structure of catalase determined by MicroED (Reprint from Ref. [26]).