Table 1.
Comparison of clinical features in patients with glomerulonephritis according to immunosuppressive treatment
| All patients (n = 229) | Immunosuppressive therapy after diagnosis | P value | ||
|---|---|---|---|---|
| None (n = 64) | Treated (n = 165) | |||
| Age at diagnosis (yr) | 49.6 (35.3-62.6) | 52.1 (37.3-61.1) | 49.2 (34.6-63.2) | 0.56 |
| Male | 103 (45.0) | 30 (46.9) | 73 (44.2) | 0.72 |
| Hypertension | 133 (58.1) | 48 (75.0) | 85 (51.5) | 0.001 |
| Systolic BP (mmHg) | 130 (118-140) | 130 (110-146) | 130 (120-139) | 0.57 |
| Diastolic BP (mmHg) | 71 (67-80) | 70 (65-80) | 72 (68-80) | 0.69 |
| Dyslipidemia | 66 (28.8) | 24 (37.5) | 42 (25.5) | 0.07 |
| Serum creatinine (mg/dL) | 1.40 (0.88-2.49) | 1.59 (0.93-2.62) | 1.28 (0.86-2.32) | 0.23 |
| eGFR (mL/min/1.73 m2) | 52.9 (26.2-90.6) | 48.7 (25.4-87.8) | 53.9 (27.3-91.7) | 0.34 |
| CKD EPI eGFR < 60 (mL/min/1.73 m2) | 133 (58.1) | 38 (59.4) | 95 (57.6) | 0.80 |
| Urine protein-to-creatinine ratio (g/g) | 4.4 (2.1-8.6) | 3.1 (1.4-5.9) | 5.5 (2.6-9.4) | < 0.001 |
| Fasting glucose (mg/dL) | 94 (88-100) | 92 (86-101) | 0.44 | |
| HbA1c (%) | 5.5 (5.1-5.7) | 5.3 (5.2-5.8) | 5.5 (5.0-5.7) | 0.74 |
| Pre-diabetes at baseline | 74 (32.3) | 24 (37.5) | 50 (30.3) | 0.29 |
| Triglyceride (mmol/L) | 1.8 (1.1-2.4) | 1.6 (1.0-2.4) | 1.8 (1.2-2.4) | 0.35 |
| LDL-C (mmol/L) | 3.9 (2.8-6.3) | 3.5 (2.6-5.0) | 4.2 (2.9-6.7) | 0.03 |
| HDL-C (mmol/L) | 1.3 (1.1-1.7) | 1.2 (1.1-1.6) | 1.3 (1.1-1.7) | 0.65 |
| Triglyceride/HDL-C ratio | 1.3 (0.8-1.9) | 1.2 (0.7-2.0) | 1.4 (0.8-1.9) | 0.54 |
Categorical variables are expressed as number (%) and compared using chi-square or Fisher’s exact test as appropriate. Continuous variables are expressed as median (interquartile range) and compared using the Mann-Whitney U test.
BP, blood pressure; CKD EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate calculated using the CKD EPI formula; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.