Table 1.
Therapies targeting peritoneal EMT
| References | Agent | Design | Model | Result |
|---|---|---|---|---|
| Sandoval et al [56] | Rosiglitazone | In vivo | Female C57BL/6 mice | Ameliorates PDS-induced EMT, angiogenesis, and peritoneal fibrosis |
| Yu et al [25] | BMP-7 or HGF | In vitro and in vivo | MCs isolated from omentum and Sprague-Dawley rats | Ameliorates EMT and peritoneal thickening |
| Jang et al [21] | Dexamethasone | In vitro | MCs isolated from omentum | Ameliorates TGFβ1-induced EMT |
| Loureiro et al [57] | Tamoxifen | In vitro and in vivo | MCs isolated from omentum/PD effluent and female C57BL/6 mice | Blocks TGFβ1-induced EMT and decreases PDS-induced peritoneal membrane thickness |
| Liu et al [58] | Selenium | In vitro | HMrSV5 (human peritoneal MC line) | Inhibits LPS-induced EMT |
| Yang et al [59] | C646 (histone acetyltransferase inhibitor) | In vitro | HMrSV5(human peritoneal MC line) | Counteracts high glucose-induced EMT |
| Yu et al [26] | Spironolactone | In vitro | MCs isolated from omentum | Inhibits aldosterone-induced EMT |
| Yu et al [26] | NAC, Apocynin or Rotenone | In vitro | MCs isolated from omentum | Inhibits aldosterone-induced EMT |
| Shin et al [27] | Metformin or AMPK agonist | In vitro and in vivo | MCs isolated from omentum and Sprague-Dawley rats | Ameliorates TGFβ1-induced EMT and PDS-induced EMT/peritoneal thickening |
| Ko et al [51] | Paricalcitol | In vitro | MCs isolated from omentum | Attenuates TGFβ1-induced EMT |
| Ko et al [51] | Blockers of NLRP3 inflammasome | In vitro | MCs isolated from omentum | Attenuates TGFβ1-induced EMT |
| Zhao et al [60] | Curcumin | In vitro | HMrSV5 (human peritoneal MC line) | Suppresses PDS-induced EMT |
| Lupinacci et al [61] | Olive leaf extract | In vitro | MeT-5A (human MC line) | Inhibits TGFβ1-induced EMT |
| Sun et al [62] | Smad-7 plasmid | In vivo | Sprague-Dawley rats | Inhibits PDS-induced peritoneal fibrosis |
| Kang et al [63] | Tranilast | In vitro and in vivo | MCs isolated from omentum and Sprague-Dawley rats | Attenuates TGFβ1-induced EMT and PDS-induced peritoneal fibrosis |
| Cheng et al [64] | Hydrogen sulfide | In vitro and in vivo | MCs isolated from omentum and Sprague-Dawley rats | Inhibit PDS-induced EMT and peritoneal fibrosis |
BMP-7, bone morphogenic peptide-7; EMT, epithelial-to-mesenchymal transition; HGF, hepatocyte growth factor; LPS, lipopolysaccharide; MCs, mesothelial cells; PD, peritoneal dialysis; PDS, peritoneal dialysis solution; TGF, transforming growth factor.