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Model of balance between the mechanism and the cellular function of the STAT1 signaling to promote radiosensitivity and radioresistance. In the radioresistant cancer cells, IR activates STAT1 signaling and trigger the function of radioresistance or radiosensitivity.
Abbreviations: EMT, epithelial-to-mesenchymal transition; IR, ionizing radiation; MHC, major histocompatibility complex; PD-L1, programmed death ligand-1; STAT1, signal transducer and activation of transcription 1.
