Figure 2. A. Map of decreases in regional GM volume over 5.8 years in 69 subjects normal at both time points. Regional volume loss is seen in ventral posterior frontal lobe, temporal pole, dorsal cerebellum and midbrain grey matter. Significance threshold is p = 0.00001; Family-wise error correction threshold was t = 5.1, indicated by the black arrowhead on the scale shown on the left. B. Increases in regional grey matter volume loss rates in baseline-diagnosed MCI compared to subjects diagnosed as normal at both baseline and repeat study (5.8 years later). Anterior hippocampus demonstrates significant excess volume loss during the MCI to AD transition (threshold p = 0.00001).