Table 2A. Overall brain initial expansion rate adjusted for covariates (adjusted volume increase rate), primarily associated with sulcal and ventricular CSF. Scores are t-values; exceptions labeled by F value. Covariates not shown in the table are age, interscan interval, education, gender, gender by diagnosis interaction, and TIV; effects associated with these covariates were not significant.

	Diagnosis at Baseline	Diagnosis at Follow-up
Overall Expansion ml/year
Normal (N)	2.97 ± 0.07 (78)	2.96 ± 0.07 (69)
AD (N)	-	3.75 ± 0.24# (7)§
MCI (N)	3.66* ± 0.25 (6)	2.95 ± 0.19 (8)
Results in Model
Diagnosis	T = −2.64/p = 0.01	F = 5.1/p = 0.01

*post hoc p = 0.01 compared to control; # post hoc p = 0.002; § 2 of these 7 subjects were diagnosed MCI at baseline, and 5 were normal at baseline.