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(A) Illustration of the fabrication of BP–Mg nanocomposite hydrogel with spatiotemporal controlled stiffness. (B) Cell response to matrix stiffening. i) fluorescence image of nuclei (blue) and F-actin (red) of hMSCs on day 16. ii) Relative gene expression of osteogenic biomarkers on day 10 and day 16. Reproduced with permission from Ref. [79], copyright 2017, John Wiley and Sons.
