Table 1.

Specific Chromosome Abnormalities Involved in Tumorigenesis and Cancer Recurrence

Cancer Type	Chromosome Abnormalities	Characteristic	Reference
Neural lineage cancers	recurrent chr7 gain	common feature	53
Glioblastoma	chr7 gain and 10 loss	without IDH mutations	53,54
	chr19q gain and 1p loss	with IDH mutations	55
Neuroblastoma	chr2p and 17q gain; chr1p and 11q deletion	common feature	55
	focal loss of chr7q14.1 and chr14q11.2	a predictive indicator for poorer prognosis	55
Low-grade glioma	chr1p and 19q deletion	responsive to chemoradiotherapy	53,57
Head and neck squamous cell carcinoma	chr3q, 5p, 8p, and 11q gain	tumorigenesis	60,61
	chr3 (3q26-29) gain	a predictive indicator for poorer prognosis	58
Oral squamous cell carcinoma	chr11q22.1-q22.2 amplification	correlation with recurrence and radiotherapy	59
Lung squamous cell carcinoma	chr3q gain and 3p loss	common feature	53
Lung adenocarcinoma	chr1q gain	cancer feature	53,63
	chr7p gain	correlation with prognosis in patients with EGFR mutation	67
Breast cancer	chr1q21.3 amplification	relation with recurrence	68
	chr16q loss	low-grade breast neoplasia	69
	Few copy number variations (CNVs) in chr17	relation with male breast cancer	70
Gastrointestinal cancer	chr3q and 8q amplifications	triple-negative breast cancer (TNBC) with lung metastasis	71
Gastrointestinal tract adenocarcinoma (GIAC)	chr13q gain	common feature	53
Esophageal squamous cell carcinoma (ESCC)	chr9p21.3 and 2q35 loss; and chr2q31.2, 3q27, 5p15.33, 7q22.1, 8q24, 8p11.23, 11q13.3 gain	common feature	74
Adrenocortical carcinoma	chr19 gain	relation with stage III/IV	75
	chr5, 12, 19, and 20 gain; and chr1, 10, 18, and 22 loss	common feature	75,76
	chr11p, 17p loss, and 9q gain	pediatric adrenocortical carcinoma	77,78
Clear cell renal cell carcinoma	chr3p loss and 9q gain	common feature	79, 80, 81
Hematologic malignancies	chr20q loss	common feature	82,83
Lymphoid neoplasms	chr1p36 loss	diffuse follicular lymphoma	84
Burkitt-like lymphoma	chr11q aberration	common feature	84
Myelodysplastic syndromes	chr5q loss	common feature	84
B cell acute lymphoblastic leukemia	chr21 gain	common feature	84
B cell precursor acute lymphoblastic leukemia (B-ALL)	chr21 gain	relation with 12q abnormalities in B-ALL	85
Testicular germ cell cancers	chr12p gain	common feature	87
Ovarian cancer and endometrial cancers	chr1q gain	common feature	53
Prostate cancer	chr16p13.3 gain	an elevated risk of distant metastases	88
	chr8q24 variation	a major contributor to prostate cancer	89