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. 2020 May 26;17:571–585. doi: 10.1016/j.omto.2020.05.009

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Safety Evaluation of CAR T Cell Therapy

(A) Flow cytometry reveals surface PD-L1 levels in different normal human cell lines. (B–E) Both PD1ACR-T and PDL1CAR-T cells show no cytolytic activity against healthy WS1 (B) and Hs181.Tes (C) cells. Both MRC-5 (D) and Hs67 (E) cell lines are sensitive to PD1ACR-T and PDL1CAR-T cells in vitro (*p< 0.05). Data are presented as the mean ± SD of three independent experiments. (F) H/E staining displays no obvious off-target toxicity against major mice organs. Original magnification, 200X. Scale bars, 100 um.