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Two models for Upf proteins curing of [PSI+u1s] variants: A. In cells missing a Upf protein, Sup35p monomers add to the ends of amyloid filaments. B. Upf proteins and the Upf1,2,3 complex compete with amyloid filaments for Sup35p monomers slowing filament growth. B. The Upf1,2,3 complex binds to the ends/growing points of amyloid filaments of Sup35p blocking addition of Sup35 monomers (56).
