Table 5.

The association of candidate genes, previously identified in the literature as associated with Alzheimer’s disease, using a gene-based test. The genes were chosen from the Alzgene (www.alzgene.org) top results ranking. Alzgene only includes findings from meta-analyses with p<0.00001 and all results are assessed for their epidemiological credibility. Please note that due to LD the p-values for APOE and TOMM40 are not independent.

Chromosome	Gene	Number of SNPs in gene	p-value All	p-value Females	p-value Males
19	APOE	19	0.0017	0.001	0.29
2	BIN1	48	0.55	0.30	0.95
8	CLU	39	0.90	0.77	0.55
19	ABCA7	34	0.15	0.13	0.42
1	CR1	44	0.44	0.088	0.99
11	PICALM	44	0.74	0.33	0.92
11	MS4A6A	10	0.70	0.15	0.72
19	CD33	26	0.80	0.55	0.98
19	TOMM40	19	0.0021	0.0014	0.32
6	CD2AP	24	0.53	0.82	0.52