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Sampling for this study within the FAVORIT (Folic Acid for Vascular Outcome Reduction in Transplantation) Trial. Among the 4,110 FAVORIT participants, we randomly selected 491 into the subcohort irrespective of allograft failure case status. We separately sampled all participants who had allograft failure during follow-up (cases). Of the 257 allograft failure cases, 49 had already been sampled into the subcohort, the remaining 208 were sampled outside of the subcohort.
