Table 4.
Mean biomarker value concentration estimated via multivariable linear regression adjusted for sex.
| Biomarker (log10),mean (SD) |
HIV+/LTBI+ N=15 |
HIV+/LTBI− N=50 |
HIV−/LTBI+ N=26 |
HIV−/LTBI− N=28 |
Significant Group Comparisons (p<0.05) |
|---|---|---|---|---|---|
| hsCRP [mg/dL] | 0.06 (0.05) | 0.17 (0.03) | 0.10 (0.04) | 0.15 (0.04) | LTBI+ < LTBI− |
| IFN-γ [pg/mL] | 1.25 (0.12) | 1.09 (0.06) | 1.06 (0.06) | 1.20 (0.09) | |
| IL-2a [pg/mL] | −0.06 (0.20) | −0.0002 (0.11) | 0.46 (0.15) | 0.07 (0.15) | |
| IL-6 [pg/mL] | 0.65 (0.17) | 0.35 (0.09) | 0.61 (0.13) | 0.38 (0.13) | LTBI+ > LTBI− |
| IL-22 [pg/mL] | 0.35 (0.24) | 0.40 (0.13) | 0.92 (0.18) | 0.78 (0.18) | HIV+ < HIV− |
| TNF-αa [pg/mL] | −0.23 (0.15) | −0.07 (0.08) | 0.18 (0.11) | 0.14 (0.11) | HIV+ < HIV− |
| MCP-1 [pg/mL] | 2.06 (0.03) | 1.97 (0.02) | 1.99 (0.03) | 1.96 (0.03) | LTBI+ > LTBI− |
| MIP-1β [pg/mL] | 0.70 (0.08) | 0.64 (0.04) | 0.61 (0.06) | 0.62 (0.06) | |
| IP-10 [pg/mL] | 1.59 (0.05) | 1.50 (0.03) | 1.51 (0.04) | 1.52 (0.04) | |
| RANTESb [pg/mL] | 1389 (110) | 1241 (59) | 1053 (83) | 1082 (83) | HIV+ > HIV− |
a
Log10-transformed values are negative for biomarker levels between 0 and 1.
b
Not log10 transformed, because the original distribution for this biomarker was already approximately normal. None of the pairwise comparisons of the 4 groups (HIV+/LTBI+, HIV+/LTBI−, HIV−/LTBI+, HIV−/LTBI−) were significant after false discovery rate adjustment. Only direct effects of HIV and LTBI were statistically significant. SE = standard error.