. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: J Crit Care. 2020 Apr 15;58:58–64. doi: 10.1016/j.jcrc.2020.04.008

Table 4.

Diagnostic Tests for CAR T-Cell Related Toxicities

Procedure	Centers, n(%) (n=11)
Lumbar Puncture	6 (55)

EEG Timing
Onset of neurotoxicity	3 (27)
Clinical suspicion of seizure	5 (46)
ICANS > grade 2	3 (27)

Routine MRI Brain
Yes	2 (18)
No	1 (9)
Attempt, but not always feasible	8 (73)

Daily CRP/Ferritin	10 (91)

Serum Cytokines
Yes, routine	4 (36)
No (not available)	3 (27)
As needed	4 (36)

Flow Cytometry for CARs	7 (64)

CAR - chimeric antigen receptor; CRP – c-reactive protein; ICANS – immune effector cell-associated neurotoxicity syndrome; EEG – electroencephalogram; MRI - magnetic resonance imaging