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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Matrix Biol. 2020 Mar 12;90:79–108. doi: 10.1016/j.matbio.2020.02.004

Fig. 11. Multifunctional roles of fibronectin in PCO pathogenesis.

Fig. 11.

This diagram depicts the multifunctional roles of cellular fibronectin in fibrotic PCO and potentially other fibrotic like conditions. (1) Regulation of fibrotic extracellular matrix protein assembly; (2) Extracellular deposition of latent TGFβ complex needed for its subsequent activation; (3) Regulation of the expression of the TGFβ signaling agonist, gremlin-1; (4) Regulation of BMP signaling; (5) Modulation of integrin signaling.