Fig. 6.

Association between T cell relative abundance and overall survival. The T cell percentage of bone marrow lymphocytes at the time of AML diagnosis was evaluated for its association with overall survival. (A) Relative hazard of death (i.e., HR of T cell percentages compared to the median value of 72.5%, indicated as 0 on the x axis) across the range of observed T cell percent, as estimated from a Cox regression model that includes patient age, ELN risk group, bone marrow WBC count, bone marrow blast percent, and AML type as covariates. The T cell percent (as a continuous measure) P value of 0.021 is from a Wald test. The shaded area denotes the simulation-derived 95% CI for the relative hazard (40). (B) Kaplan–Meier survival curves for “low” (red) and “high” (blue) T cell percentage groups, defined by dichotomizing on the sample median of 72.5%. The P value of 0.030 is from the log-rank (or score) test and HR of 0.50 is estimated from a univariable Cox model.