Fig. 1.

Expression of IL-12p70 subunits during PFAPA flares and comparison of IL-12p70 production according to IL12A risk allele. During PFAPA flares, a higher percentage of patient CD14⁺ monocytes express both subunits of IL-12p70, p35 and p40, compared with nonflare periods and with healthy controls; ex vivo FACS analysis of PBMCs (A). Peripheral blood CD14⁺ monocytes from adults homozygous and heterozygous for the risk allele near IL12A (rs17753641) secrete more IL-12p70 following priming with IFN-γ and stimulation with LPS than monocytes from individuals without the risk allele; ELISA on supernatant of in vitro-stimulated cells (B). Each dot represents an individual. Mean and SD are plotted. *P < 0.05, **P < 0.005.