Table 2.

Classical HLA allele associations in cohorts of European and Turkish ancestry and metaanalyses of these two cohorts

Classical HLA type	Frequency of dominant genotype among PFAPA cases*	Frequency of dominant genotype among controls†	OR	P value	ORmeta (95% CI)	Pmeta	Bonferroni corrected Pmeta‡
HLA-DQB1*06:03§	0.18	0.12	1.83	0.006	2.13 (1.50–3.03)	2 × 10−5	0.0002
	0.28	0.11	3.32	0.002
HLA-DRB1*13:01§	0.18	0.12	1.79	0.008	2.04 (1.43–2.91)	9 × 10−5	0.0009
	0.26	0.11	2.97	0.005
HLA-DQA1*01:03§	0.20	0.13	1.83	0.004	1.97 (1.40–2.77)	0.0001	0.001
	0.32	0.17	2.44	0.015
HLA-B*15:01	0.19	0.13	2.00	0.001	1.96 (1.33–2.89)	0.0007	0.007
	0.043	0.035	1.48	0.62
HLA-B*35:02	0.05	0.01	3.61	0.003	2.86 (1.56–5.26)	0.0007	0.007
	0.13	0.07	1.88	0.24
HLA-DPA1*02:02	0.12	0.06	2.03	0.01	1.93 (1.23–3.04)	0.004	0.04
	0.11	0.08	1.61	0.36

^*Values are listed in the following order: Caucasian cases (n = 185); Turkish cases (n = 47).

^†Values are listed in the following order: Caucasian controls (n = 5,437); Turkish controls (n = 1,779). HLA types of the 5437 Caucasian controls were previously reported in Gourh et al. (19).

^‡Metaanalysis P values (P_meta) were corrected for 10 comparisons with Bonferroni correction.

^§These HLA alleles are in LD.