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. 2020 Jun 8;117(25):14395–14404. doi: 10.1073/pnas.1918596117

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Fig. 3. — The expression of TRIM25 regulated by RIG-I. (A and B) The mRNA (A) and protein (B) levels of TRIM25 in NB4 cells with ATRA treatment. (C and D) The mRNA (C) and protein (D) levels of TRIM25 in U937-RIG-I cells with RIG-I induction upon doxycycline depletion. (E) Down-regulation of TRIM25 expression upon the knockdown of RIG-I in NB4 cells. (F) Up-regulation of TRIM25 protein by overexpressing the CARD, CTD, and helicase domain of RIG-I in HEK 293T cells, respectively. (G) The transcriptional level of TRIM25 was up-regulated upon the overexpression of three distinct domains of RIG-I in HEK 293T cells.