Fig. 4.

Aggressive tumor growth: tumors with doubling the proliferation rate λ, increasing tumor cell lysis rate by one third, and reducing the chemotactic coefficient to be one thirtieth of its estimated value are considered to be aggressive gliomas. (A) Numerical results show that there is only one day difference in survivals for wtIDH1 and muIDH1 aggressive tumors. (B) Experimental data for tumor mice in Ink4a/Arf^−/− background: 42 wtIDH1 tumor mice have a median survival of 36 days while 65 muIDH1 tumor mice have a median survival of 35 days. (C) Mathematical model prediction for profiles of infiltrated immune cells. (D) Truncations of infiltrated immune cell percentages, 0.5% and 0.1% for wtIDH1 tumor and muIDH1 tumor, respectively, when mice die.