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Diffuse infiltration of A20 cells and partial infiltration of THP-1 cells into the bone marrow. Fourteen (a, b, e, f) or 21 (c, d, g, h) days after transplantation, histological changes in bone marrow were evaluated in serial sections (a–b, c–d, e–f, g–h) using H&E staining (a, c, e, g) and tumor cells (arrows) were detected with immunostaining for B220 in A20 leukemia mouse models (b, d), and for CD31 in THP-1 mouse models (f, h). BM; bone marrow, CB; cortical bone. Bars = 500 μm.
