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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Anesthesiology. 2020 Jun;132(6):1540–1553. doi: 10.1097/ALN.0000000000003241

Figure 5. Transcriptional increases of anti-inflammatory cytokines in DRGs of paclitaxel-treated mice after local sympathectomy.

Figure 5.

Transcriptional expression levels in DRGs 7 days after paclitaxel treatment in male mice with sham surgery or local microsympathectomy (mSYMPX). Transcriptional analyses of: (A) the macrophage pro-inflammatory marker nitric oxide synthase 2 (NOS2) and anti-inflammatory marker arginase 1 (ARG1); (B) pro-inflammatory cytokines interleukins (IL) IL-1β, IL-6 and tumor necrosis factor alpha (TNFα); as well as (C) anti-inflammatory cytokines IL-4, IL-10, and TGF-β, and its receptor TGF-βR1. For A-C, n=4 male mice/group, t-test, *p < 0.05, **p < 0.01 compared to sham.