Table 4.

Incremental Value of Resting HR and CIx in Predicting Adverse Clinical Events Beyond Clinical Variables

Factors	C-Statistic (95% CI) without CIx	C-Statistic (95% CI) with CIx	P Value	NRI (95% CI) for Composite Events at 2 y	P Value	IDI (95% CI) for Composite Events at 2 y	P Value
Clinical + resting HR	0.72 (0.68–0.76)	0.76 (0.72–0.79)	.005	27.0% (10.2%–37.0%)	<.001	4.2% (1.5%–8.5%)	.008
Clinical + resting HR + peak VO2	0.76 (0.72–0.79)	0.77 (0.73–0.80)	.16	15.2% (0.6%–28.9%)	.024	1.2% (−0.2% to 3.7%)	.12

Clinical variables: age, sex, cardiomyopathy etiology, diabetes, LVEF, β-blocker use, presence of CRT/ICD, eGFR. IDI, integrated discrimination improvement; NRI, net reclassification improvement; other abbreviations as in Table 1.