Figure 4.
(a) Network representation of the dataset. Each node represents a domain. Each domain is colored according to its SCOP class. The links connect domains that have a fragment in common. Since a domain might contain several distinct fragments, it can appear several times in the network. Cutoffs to build this network were: probability > 70%, RMSDTM < 3 Å, TM-score > 0.3, and the length of the sequence alignment was at most 25% larger than the structural alignment. (b) A closer view to the major component (fragment 0) and the folds that populate it in its different regions. Labels indicate where the relationships between two folds occur, for example, c.1–c.23. Note that most connections occur with the Rossmann fold (c.2) in the blue region and with the DNA/RNA-binding 3-helical bundle (a.4) in the orange region. The largest distance between any two pair of nodes in this network is 21.