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. 2020 Jan 17;432(2):552–568. doi: 10.1016/j.jmb.2019.11.016

Table 1.

Overview of apoptosis, pyroptosis, and necroptosis.

Apoptosis Pyroptosis Necroptosis
Cellular events cell shrinkage
DNA fragmentation apoptotic bodies		 pore formation
loss of plasma membrane integrity
swollen cellular organelles
Inflammation noninflammatory proinflammatory
Key proteinsa caspase-3 ASC
caspase-1
GSDMD		 RIPK3
MLKL
DNA sensorsa cGAS-STING
TLR9		 AIM2
IFI16
RNA sensorsa RIG-I
MDA5		 NLRP3
NLRP9b		 TLR3
ZBP1
a

Selected examples, please see text for further details.