Table 1.
Two-component systems in S. aureus and S. saprophyticus
| Two-component system | S. aureus | S. saprophyticus | Function |
|---|---|---|---|
| walRK | MW0018 | SSP0021 | Cell wall maintenance, cell viability |
| MW0019 | SSP0022 | ||
| hptSR | MW0198 | Intracellular survival, uptake of hexose phosphate | |
| MW0199 | |||
| lytSR | MW0236 | SSP0463 | Autolysis, eDNA release, biofilm |
| MW0237 | SSP0464 | ||
| graRS | MW0621 | SSP2061 | AMPs resistance, growth at low pH |
| MW0622 | SSP2062 | ||
| saeSR | MW0667 | Virulence factors regulation (toxins, exoenzymes…) | |
| MW0668 | |||
| tcs7SR | MW1208 | SSP1446 | Uncharacterized function |
| MW1209 | SSP1547 | ||
| arlSR | MW1304 | SSP1323 | Pathogenesis mechanisms: autolysis, adhesion, biofilm… |
| MW1305 | SSP1324 | ||
| srrBA | MW1445 | SSP1260 | Anaerobic respiration metabolism, growth at low temperature |
| MW1446 | SSP1261 | ||
| phoRP | MW1636 | SSP1073 | Phosphate uptake and homeostasis |
| MW1637 | SSP1074 | ||
| airRS | MW1789 | SSP0946 | Oxidative stress response |
| MW1790 | SSP0947 | ||
| vraRS | MW1824 | SSP0908 | Cell wall-affecting antibiotic resistance, cell wall biosynthesis |
| MW1825 | SSP0909 | ||
| agrCA | MW1962 | SSP0839 | Quorum sensing control of adhesion and virulence factors |
| MW1963 | SSP0840 | ||
| kdpDE | MW2002 | Potassium homeostasis regulation | |
| MW2003 | |||
| hssRS | MW2282 | SSP0540 | Heme metabolism regulation |
| MW2283 | SSP0541 | ||
| nreCB | MW2313 | Response to low oxygen, nitrate reduction | |
| MW2314 | |||
| braSR | MW2544 | Antimicrobial peptide resistance | |
| MW2545 |