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. 2020 Apr 27;29(10):1673–1688. doi: 10.1093/hmg/ddaa076

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlation between gene expression levels of TWIST1, EMT and CIN across human cancers. (A) TWIST1 gene expression (log2 RSEM + 0.01) level within and across cancers of TCGA. Each dot represents a tumor sample and the horizontal red bar indicates the median expression value within that cancer cohort. The cancer type abbreviations are shown below. (B) TWIST1 expression in colorectal cancers (COADREAD) stratified by tumor stages. (C) Heatmap representing the correlation coefficient (and its significance) between TWIST1 expression and (i) EMT, (ii) CIN, (iii) DSB gene expression, (iv) mutation count and (v) copy number alteration (CNA) fraction for all 30 distinct cancers, computed using an iteratively reweighted least-squares approach. Color coding indicates the correlation coefficient, ranging from −1 to +1, where −1 being strong negative correlation (dark blue), 0 for no correlation (white) and +1 strong positive correlation (dark red). Significant correlations (q < 0.01) are marked with an asterisk (^*). Cancer type abbreviations: ACC: adrenocortical carcinoma, BLCA: bladder urothelial carcinoma, BRCA: breast invasive carcinoma, CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma, CHOL: cholangiocarcinoma, COADREAD: colorectal adenocarcinoma, DLBC: diffuse large B-cell lymphoma, ESCA: esophageal carcinoma, GBM: glioblastoma multiforme, HNSC: head and neck squamous cell carcinoma, KIPAN: pan kidney carcinomas, LAML: acute myeloid leukemia, LIHC: liver hepatocellular carcinoma, LGG: brain lower grade glioma, LUAD: lung adenocarcinoma, LUSC: lung squamous cell carcinoma, MESO: mesothelioma, OV: ovarian serous cystadenocarcinoma, PAAD: pancreatic adenocarcinoma, PCPG: pheochromocytoma and paraganglioma, PRAD: prostate adenocarcinoma, SARC: sarcoma, SKCM: skin cutaneous melanoma, STAD: stomach adenocarcinoma, TGCT: testicular germ cell tumors, THCA: thyroid carcinoma, THYM: thymoma, UCS: uterine carcinosarcoma, UCEC: uterine corpus endometrial carcinoma, UVM: uveal melanoma.