Table 1.
|
All cases | Follow-up to the second evaluation | ||||
n = 1227 |
n = 445 |
|||||
First evaluation | Last evaluation | First evaluation | Second evaluation | Paired t-test p (1st and 2nd) | ||
Follow-up | years | 4.4 ± 2.9 | 7.4 ± 1.2 | |||
Age at onset | years | 57.8 ± 11.7 | 54.9 ± 12.3 | |||
Age | years | 67.2 ± 9.9 | 71.5 ± 9.5 | 62.5 ± 10.7 | 69.8 ± 10.5 | |
Sex (female) | 676 | 55% | 249 | 56% | ||
Hoehn and Yahr stage | 2.7 ± 1.1 | 3.5 ± 1.1 | 2.30 ± 1.1 | 3.3 ± 1.1 | <0.001 | |
Total LED | mg | 756 ± 423.0 | 873.6 ± 384.3 | 697.8 ± 433.0 | 896.5 ± 367.2 | <0.001 |
Dopamine agonist LED | mg | 149.5 ± 140.9 | 104.3 ± 138.0 | 189.7 ± 153.0 | 131.9 ± 146.1 | <0.001 |
Levodopa | n | 1088 | 1202 | 356 | 434 | |
mg | 541.9 ± 303.7 | 655.9 ± 287.1 | 479.3 ± 288.3 | 636.6 ± 259.2 | <0.001 | |
Pramipexole | n | 777 | 312 | 299 | 92 | |
mg | 2.0 ± 1.3 | 2.3 ± 1.1 | 2.0 ± 1.3 | 2.3 ± 1.1 | ||
Ropinirole | n | 184 | 122 | 80 | 68 | |
mg | 7.3 ± 3.2 | 8.8 ± 2.9 | 8.0 ± 3.7 | 10.0 ± 3.8 | ||
Rotigotine | n | — | 149 | — | 97 | |
mg | — | 8.1 ± 4.0 | — | 8.3 ± 4.1 | ||
Pergolide | n | 325 | 39 | 108 | 8 | |
mg | 1.0 ± 0.5 | 1.0 ± 0.2 | 1.0 ± 0.5 | 1.3 ± 0.2 | ||
Cabergoline | n | 329 | 12 | 117 | 0 | |
mg | 2.4 ± 1.3 | 2.6 ± 0.3 | 2.7 ± 1.4 | 0 | ||
Selegiline | n | 517 | 228 | 178 | 103 | |
mg | 4.9 ± 2.8 | 5.1 ± 2.2 | 5.1 ± 2.9 | 5.2 ± 2.4 | ||
Entacapone | n | 264 | 372 | 100 | 192 | |
mg | 486.2 ± 229.2 | 533.6 ± 285.1 | 502.1 ± 240.0 | 535.2 ± 319.0 | ||
Istradefylline | n | — | 75 | — | 50 | |
mg | — | 29.9 ± 7.6 | — | 29.6 ± 9.9 | ||
Trihexyphenidyl | n | 480 | 169 | 168 | 42 | |
mg | 3.2 ± 1.9 | 2.7 ± 1.0 | 3.6 ± 2.1 | 3.3 ± 1.0 | ||
Amantadine | n | 320 | 106 | 150 | 110 | |
mg | 166.7 ± 91.1 | 176.0 ± 85.3 | 181.7 ± 94.4 | 194.3 ± 91.8 | ||
Zonisamide | n | 106 | 291 | 46 | 151 | |
mg | 10.9 ± 25.0 | 44.4 ± 24.9 | 45.4 ± 17.5 | 47.3 ± 30.0 | ||
Droxidopa | n | 105 | 79 | 27 | 30 | |
mg | 382.9 ± 118.9 | 498.1 ± 134.6 | 396.4 ± 107.3 | 464.5 ± 127.9 | ||
Cholinesterase inhibitor | n | 89 | 259 | 13 | 87 | |
Memantine | n | — | 89 | — | 40 | |
Midodrine | n | 44 | 66 | 11 | 23 |