Table 3.
Metabolite pathway changes between sham and AD groups.
| No. | Pathway | Hits | Total | p | −Log(p) | FDR p | Impact |
|---|---|---|---|---|---|---|---|
| 1 | Sphingolipid metabolism | 3 | 21 | 0.0011 | 0.0901 | 0.46248 | |
| 2 | Glycerophospholipid metabolism | 3 | 36 | 0.0052 | 5.2518 | 0.21999 | 0.21631 |
| 3 | Linoleic acid metabolism | 1 | 5 | 0.0506 | 2.9834 | 1 | 0 |
| 4 | Alpha-linolenic acid metabolism | 1 | 13 | 0.1266 | 2.0663 | 1 | 0 |
| 5 | Glycosylphosphatidylinositol (GPI) anchor biosynthesis | 1 | 14 | 0.1357 | 1.997 | 1 | 0.00399 |
| 6 | Cysteine and methionine metabolism | 1 | 33 | 0.2925 | 1.2293 | 1 | 0.05271 |
| 7 | Arachidonic acid metabolism | 1 | 36 | 0.3147 | 1.1562 | 1 | 0 |
| 8 | Arginine and proline metabolism | 1 | 38 | 0.3291 | 1.1115 | 1 | 0 |
| 9 | Purine metabolism | 1 | 65 | 0.4979 | 0.69746 | 1 | 0.02939 |
Hits represent the matched number of metabolites in one pathway. p represents the original p value calculated from the enrichment analysis. FDR p represents the p value adjusted using the false discovery rate.