Table 5.
Differentially expressed lipids detected by LC-MS/MS.
| Lipid ion | Class | Ion formula | m/z | Rt (min) | AD vs. sham | BSTSF vs. AD | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| p | VIP | FC | p | VIP | FC | |||||
| ESI+ | ||||||||||
| Cer(d18:1/24:1) | Cer | C42 H82 O3 N1 | 648.6289 | 18.24252 | 0.016 | 1.420 | 1.373 | — | — | — |
| PE(20:3e) | PE | C25 H46 O7 N1 P1 Na1 | 526.2904 | 3.140912 | 0.004 | 1.102 | 1.646 | — | — | — |
| Cer(d18:1/18:0) | Cer | C36 H72 O3 N1 | 566.5507 | 15.29891 | 0.007 | 6.805 | 1.529 | 0.002 | 1.724 | 0.646 |
| Cer(d20:1/18:0) | Cer | C38 H76 O3 N1 | 594.582 | 16.73516 | 0.003 | 1.898 | 1.507 | — | — | — |
| LPC(16:0) | LPC | C24 H51 O7 N1 P1 | 496.3398 | 4.266847 | 0.041 | 2.016 | 1.533 | — | — | — |
| Cer(d18:2/20:2) | Cer | C38 H70 O3 N1 | 588.535 | 15.19771 | 0.033 | 3.174 | 1.304 | 0.003 | 2.537 | 0.747 |
| LPC(18:0) | LPC | C26 H55 O7 N1 P1 | 524.3711 | 5.993806 | 0.046 | 1.211 | 1.417 | — | — | — |
| PC(32:1e) | PC | C40 H81 O7 N1 P1 | 718.5745 | 14.22706 | — | — | — | 0.007 | 1.014 | 0.718 |
| PC(38:4) | PC | C46 H85 O8 N1 P1 | 810.6007 | 13.76129 | — | — | — | 0.011 | 3.016 | 0.872 |
| PE(16:0p/20:4) | PE | C41 H75 O7 N1 P1 | 724.5276 | 13.45675 | — | — | — | 0.018 | 2.391 | 0.778 |
| Cer(d18:2/18:0) | Cer | C36 H70 O3 N1 | 564.535 | 14.0985 | — | — | — | 0.021 | 1.147 | 0.784 |
| PE(37:1p) | PE | C42 H82 O7 N1 P1 Na1 | 766.5721 | 13.06318 | — | — | — | 0.030 | 1.838 | 0.735 |
| PS(18:1/22:6) | PS | C46 H77 O10 N1 P1 | 834.528 | 11.2969 | — | — | — | 0.033 | 1.718 | 0.663 |
| PC(34:1e) | PC | C42 H85 O7 N1 P1 | 746.6058 | 15.56148 | — | — | — | 0.042 | 2.541 | 1.515 |
| ESI- | ||||||||||
| PS(20:3/22:6) | PS | C48 H75 O10 N1 P1 | 856.5134 | 11.75541 | 0.030 | 1.406 | 0.815 | 0.021 | 1.537 | 1.279 |
| SM(d16:1/18:0) | SM | C40 H80 O8 N2 P1 | 747.5658 | 11.40332 | 0.020 | 1.280 | 0.817 | — | — | — |
| Cer(d18:1/16:0) | Cer | C35 H68 O5 N1 | 582.5103 | 12.79807 | 0.009 | 1.942 | 1.367 | — | — | — |
| Cer(d15:0/20:1) | Cer | C36 H70 O5 N1 | 596.5259 | 13.38667 | 0.004 | 1.052 | 1.439 | — | — | — |
| Cer(d36:0) | Cer | C37 H74 O5 N1 | 612.5572 | 14.35006 | 0.002 | 2.378 | 1.598 | 0.002 | 1.160 | 0.704 |
| Cer(d16:0/21:1) | Cer | C38 H74 O5 N1 | 624.5572 | 14.49407 | 0.014 | 1.254 | 1.464 | — | — | — |
| Cer(d20:1/18:0) | Cer | C39 H76 O5 N1 | 638.5729 | 15.25846 | 0.002 | 4.956 | 1.382 | 0.008 | 2.903 | 0.811 |
| Cer(d18:1/22:0) | Cer | C41 H80 O5 N1 | 666.6042 | 16.5813 | 0.000 | 1.921 | 1.404 | — | — | — |
| Cer(d18:1/22:1) | Cer | C41 H78 O5 N1 | 664.5885 | 15.15109 | 0.018 | 1.171 | 1.486 | — | — | — |
| Cer(d18:1/23:0) | Cer | C42 H82 O5 N1 | 680.6198 | 17.28717 | 0.001 | 1.368 | 1.431 | — | — | — |
| Cer(d18:1/24:0) | Cer | C43 H84 O5 N1 | 694.6355 | 17.99214 | 0.002 | 1.893 | 1.423 | — | — | — |
| Cer(d18:1/24:1) | Cer | C43 H82 O5 N1 | 692.6198 | 16.51347 | 0.014 | 3.881 | 1.372 | — | — | — |
| LPC(16:0) | LPC | C25 H51 O9 N1 P1 | 540.3307 | 3.236844 | 0.000 | 1.157 | 1.460 | — | — | — |
| LPC(18:0) | LPC | C27 H55 O9 N1 P1 | 568.362 | 4.929942 | 0.016 | 1.612 | 1.386 | — | — | — |
| LPC(18:1) | LPC | C27 H53 O9 N1 P1 | 566.3463 | 3.43383 | 0.002 | 1.347 | 1.474 | — | — | — |
| LPC(20:4) | LPC | C29 H51 O9 N1 P1 | 588.3307 | 2.702941 | 0.023 | 1.167 | 1.610 | — | — | — |
| LPE(20:4) | LPE | C25 H43 O7 N1 P1 | 500.2783 | 2.830786 | 0.002 | 1.657 | 1.552 | — | — | — |
| LPE(22:6) | LPE | C27 H43 O7 N1 P1 | 524.2783 | 2.696826 | 0.002 | 2.536 | 1.640 | — | — | — |
| PC(18:0/20:4) | PC | C47 H85 O10 N1 P1 | 854.5917 | 12.64714 | 0.004 | 1.505 | 1.103 | 0.007 | 1.605 | 0.907 |
| PC(16:0/22:5) | PC | C47 H83 O10 N1 P1 | 852.576 | 12.042 | 0.046 | 1.805 | 1.422 | — | — | — |
| PE(16:0p/22:6) | PE | C43 H73 O7 N1 P1 | 746.513 | 11.99096 | 0.016 | 3.248 | 1.112 | 0.009 | 3.056 | 0.902 |
| PE(18:1p/22:6) | PE | C45 H75 O7 N1 P1 | 772.5287 | 12.0979 | 0.009 | 1.202 | 1.104 | — | — | — |
| PG(42:6) | PG | C48 H82 O10 N0 P1 | 849.5651 | 11.75907 | 0.022 | 1.445 | 1.248 | — | — | — |
| PC(16:0/20:4) | PC | C45 H81 O10 N1 P1 | 826.5604 | 11.53414 | — | — | — | 0.005 | 1.825 | 0.887 |
| PE(18:0p/20:4) | PE | C43 H77 O7 N1 P1 | 750.5443 | 13.11735 | — | — | — | 0.009 | 2.226 | 0.894 |
| PE(18:0/22:4) | PE | C45 H81 O8 N1 P1 | 794.5705 | 13.64911 | — | — | — | 0.017 | 1.971 | 0.905 |
| PS(18:0/22:6) | PS | C46 H77 O10 N1 P1 | 834.5291 | 13.47165 | — | — | — | 0.027 | 1.376 | 2.309 |
| PE(34:1e) | PE | C39 H77 O7 N1 P1 | 702.5443 | 13.497 | — | — | — | 0.030 | 1.789 | 1.250 |
| PE(18:0/20:4) | PE | C43 H77 O8 N1 P1 | 766.5392 | 12.85352 | — | — | — | 0.038 | 2.780 | 0.924 |
| PS(18:0/18:1) | PS | C42 H79 O10 N1 P1 | 788.5447 | 12.64461 | — | — | — | 0.044 | 2.484 | 1.284 |
Notes: BSTSF: Bushen Tiansui Formula; AD: Alzheimer's disease; RT (min): retention time; VIP: variable importance; FC: fold change. Fold change was calculated as average relative quantitation obtained from group 1/group 2, and a value less than 1 indicates a decrease in the metabolites of group 1.