. 2020 Jun 19;2020:1302453. doi: 10.1155/2020/1302453

Table 2.

The 90 enriched genes associated with cardiovascular diseases analyzed with the Comparative Toxicogenomics Database.

Disease name	Disease categories	P value	Corrected P value	Annotated gene quantity	Annotated genes	Genome frequency
Cardiovascular diseases	Cardiovascular disease	2.81E-13	3.78E-10	90	ANXA1\|ATP7A\|BRAF\|CALM2\|CALU\|CAMK2D\|CANX\|CASP12\|CASQ2\|CCL2\|COX1\|COX2\|COX3\|CRBN\|CXCL1\|CYTB\|des\|DNM1L\|EIF2A\|ERAP1\|FKBP14\|FKTN\|GAA\|GATAD1\|GLRX3\|GSTA4\|GSTT1\|HIF1A\|HMGB1\|HMOX1\|HSF2\|HSPA9\|HSPD1\|JAK2\|KLF13\|KRAS\|MAOA\|MAPRE1\|MEX3C\|MFF\|NCL\|ND1\|ND5\|ND6\|NDUFS1\|NEDD4\|NEXN\|NF1\|NR3C1\|NR4A1\|NRAS\|NUCKS1\|NUP155\|PAK2\|PDIA3\|PON2\|PPP2CA\|PPP3R1\|PROS1\|PSEN2\|PSMA2\|PSMA6\|PSMB7\|PTP4A2\|RASA1\|RENBP\|ROCK2\|SCN1B\|SGCA\|SGCD\|SHOC2\|SIRT4\|SLC4A3\|STK39\|TAP1\|TBCA\|TFPI\|TFRC\|TLL1\|TNFAIP6\|TRIM63\|TRPM4\|UFD1\|UGCG\|USP34\|WDPCP\|WDR12\|WNK4\|XPO1\|YES1	1452/43293 genes: 3.35%

Heart diseases	Cardiovascular disease	7.42E-11	9.97E-08	68	BRAF\|CALM2\|CALU\|CAMK2D\|CANX\|CASP12\|CASQ2\|CCL2\|COX1\|des\|DNM1L\|EIF2A\|FKTN\|GAA\|GATAD1\|GLRX3\|HIF1A\|HMGB1\|HMOX1\|HSF2\|HSPA9\|HSPD1\|JAK2\|KLF13\|KRAS\|MAPRE1\|MEX3C\|MFF\|NCL\|NDUFS1\|NEDD4\|NEXN\|NF1\|NR3C1\|NR4A1\|NRAS\|NUCKS1\|NUP155\|PAK2\|PDIA3\|PPP2CA\|PPP3R1\|PSEN2\|PSMA2\|PSMA6\|PSMB7\|PTP4A2\|RENBP\|ROCK2\|SCN1B\|SGCA\|SGCD\|SHOC2\|SIRT4\|SLC4A3\|TAP1\|TBCA\|TFRC\|TLL1\|TRIM63\|TRPM4\|UFD1\|UGCG\|USP34\|WDPCP\|WDR12\|XPO1\|YES1	1066/43293 genes: 2.46%

MELAS syndrome	Cardiovascular disease \|Genetic disease (inborn) \|Metabolic disease \|Musculoskeletal disease \|Nervous system disease	1.20E-06	0.00161	7	COX1\|COX2\|COX3\|CYTB\|ND1\|ND5\|ND6	22/43293 genes: 0.05%

Vascular diseases	Cardiovascular disease	2.59E-06	0.00348	50	ANXA1\|ATP7A\|CAMK2D\|CANX\|CASP12\|CCL2\|COX1\|COX2\|COX3\|CRBN\|CXCL1\|CYTB\|DNM1L\|EIF2A\|ERAP1\|FKBP14\|GSTA4\|GSTT1\|HIF1A\|HMGB1\|HMOX1\|HSPA9\|HSPD1\|JAK2\|KLF13\|KRAS\|MAOA\|MAPRE1\|MFF\|NCL\|ND1\|ND5\|ND6\|NEDD4\|NR3C1\|NR4A1\|PDIA3\|PPP2CA\|PPP3R1\|PROS1\|PSMA6\|RASA1\|STK39\|TAP1\|TFPI\|TFRC\|TNFAIP6\|UGCG\|WDR12\|WNK4	917/43293 genes: 2.12%

Cardiomegaly	Cardiovascular disease \|Pathology (anatomical condition)	3.31E-06	0.00444	17	CASQ2\|des\|FKTN\|GAA\|GATAD1\|GLRX3\|HIF1A\|HMOX1\|NEXN\|PPP3R1\|PSEN2\|RENBP\|ROCK2\|SGCD\|SIRT4\|TRIM63\|WDR12	168/43293 genes: 0.39%

Cardiomyopathies	Cardiovascular disease	5.17E-06	0.00695	22	CASP12\|CASQ2\|CCL2\|COX1\|des\|FKTN\|GAA\|GATAD1\|HIF1A\|HMGB1\|HSPD1\|NDUFS1\|NEXN\|PSEN2\|RENBP\|SGCA\|SGCD\|SIRT4\|TBCA\|TFRC\|TRIM63\|WDR12	271/43293 genes: 0.63%

Cerebral small vessel diseases	Cardiovascular disease \|Nervous system disease	5.56E-06	0.00747	7	COX1\|COX2\|COX3\|CYTB\|ND1\|ND5\|ND6	27/43293 genes: 0.06%