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. Author manuscript; available in PMC: 2020 Jun 29.
Published in final edited form as: Clin Cancer Res. 2009 Mar 17;15(7):2514–2522. doi: 10.1158/1078-0432.CCR-08-1254

Table 1.

Schedule of siplizumab administration cohorts 1 to 10

Siplizumab doses (mg/kg)
Day 1 Day 2 Day 3 Patients enrolled
Cohort 1 0.2 0.2 3
Cohort 2 0.2 0.2 0.2 3
Cohort 3 0.4 0.4 3
Cohort 4 0.4 0.4 0.4 4
Cohort 5 0.4 0.8 1.2 3
Cohort 6 0.4 1.2 1.8 3
Cohort 7 0.4 1.8 2.6 3
Cohort 8 0.8 3
Cohort 9 3.4 3
Cohort 10 4.8 1

NOTE: Cohorts 1 to 7 received a cycle every 14 d, whereas cohorts 8 to 10 received a single-day dose days 1 and 14 and then weekly administration.