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Schedule of siplizumab administration cohorts 1 to 10
| Siplizumab doses (mg/kg) | ||||
|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Patients enrolled | |
| Cohort 1 | 0.2 | 0.2 | — | 3 |
| Cohort 2 | 0.2 | 0.2 | 0.2 | 3 |
| Cohort 3 | 0.4 | 0.4 | — | 3 |
| Cohort 4 | 0.4 | 0.4 | 0.4 | 4 |
| Cohort 5 | 0.4 | 0.8 | 1.2 | 3 |
| Cohort 6 | 0.4 | 1.2 | 1.8 | 3 |
| Cohort 7 | 0.4 | 1.8 | 2.6 | 3 |
| Cohort 8 | 0.8 | — | — | 3 |
| Cohort 9 | 3.4 | — | — | 3 |
| Cohort 10 | 4.8 | — | — | 1 |
NOTE: Cohorts 1 to 7 received a cycle every 14 d, whereas cohorts 8 to 10 received a single-day dose days 1 and 14 and then weekly administration.
