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TIS11D is recurrently mutated in leukemias. (A) Direct sequence analysis of DNA from an AML patient (M30) and the DG75 cell line revealed frameshift mutations in TIS11D. (B) SNP array profile of chromosome 2 in the DG75 cell line showing an 18 Mb deletion including the TIS11D locus, indicating hemizygous mutation. Seventeen Burkitt’s lymphoma cell lines were analyzed simultaneously.
