Table 3.

miRNAs that modulate antioxidant expression or activity.

miRNAs	Targeted Antioxidant	Model	References
miR-7	Inhibit Keap1/activates Nrf2pathway	Human neuroblastoma cell line	[101]
miR-21	Extracellular Cu/ZnSOD inhibition MnSOD downregulation	Human bronchial epithelial cells	[82]
miR 27ab	Inhibit Nrf2 expression	Chronic cholestatic liver injury	[50]
miR-30b	Inhibit Catalase expression	Retinal pigment epithelial cell line	[84]
miR-93	Decrease Nrf2 level	Breast carcinogenesis	[99]
miR-101	Inhibits Cul3/stabilizes Nrf2	HUVEC cells and aortic rings	[173]
miR-144	GR (modulated?) Decrease GPx expression Decrease Nrf2 level	Primary erythroid progenitor cells Human neuroblastoma SH-SY5Y cells Primary erythroid progenitor cells Alveolar epithelial dysfunction in HIV-1 transgenic rats	[94] [174] [94] [175]
miR-146a	Decrease Catalase expression	Human lung cancer cells	[85]
miR-181a	Decrease GPx expression	Rat cardiomyocyte cell line	[91]
miR-185	Decrease GPx expression	Alcoholic liver disease Human endothelial cells	[92] [93]
miR-200a	Inhibit Keap1/activates Nrf2 pathway	Breast carcinogenesis Liver inflammation	[100] [176]
miR-212	Supress MnSOD expression	Colorectal tumor	[67]
miR-214	Increase GPx activity Decreased GR activity	Diabetic nephropathy Alcohol induced liver injury	[95] [96]
miR-206	Intracellular Cu/ZnSOD inhibition	Canine model of atrial fibrillation	[83]
miR-200c	Supress Nrf2 expression	Lung cancer cells	[98]
miR-455	Inhibits Cul3/activates Nrf2	Human osteoblasts	[102]
miR-551b	Decrease Catalase expression	Lung Cancer model	[86]