TABLE 1.
Genotypic association of SNPs in SNCA and MAPT with PD risk adjusted by sex, age, and multiple testing adjustments of P values
| PD | Control | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Alleles, M/m | Freq. 11 | Freq. 12 | Freq. 22 | Freq. 11 | Freq. 12 | Freq. 22 | OR (95% CI) | Model | Genotypic P value | Adj. Gen. P value |
| SNCA | rs356219 | A (1)/G (2) | 0.36 | 0.47 | 0.17 | 0.45 | 0.44 | 0.11 | 1.36 (1.18–1.56) | Log-additive | <.0001 | <.0027 |
| MAPT | rs1800547 | A (1)/G (2) | 0.56 | 0.38 | 0.06 | 0.49 | 0.41 | 0.11 | 1.33 (1.15–1.54) | Log-additive | .0001 | .0027 |
| DDIT4L | rs1053227 | G (1)/A (2) | 0.33 | 0.49 | 0.18 | 0.37 | 0.49 | 0.14 | 0.84 (0.73–0.96) | Log-additive | .0100 | 1350 |
| EIF4EBP1 | rs6605631 | T (1)/C (2) | 0.69 | 0.29 | 0.02 | 0.66 | 0.29 | 0.05 | 1.98 (1.16–3.38) | Recessive | .0100 | .1350 |
| LPIN1 | rs7595221 | A (1)/G (2) | 0.29 | 0.48 | 0.23 | 0.25 | 0.53 | 0.22 | 1.23 (1.02–1.49) | Overdominant | .0270 | .2916 |
| PRKCA | rs887797 | G (1)/A (2) | 0.48 | 0.40 | 0.12 | 0.43 | 0.45 | 0.12 | 1.22 (1.01–1.48) | Overdominant | .0360 | .2922 |
Statistically significant P values are bold. Genotypic test calculated in SNPstats software with sex and age adjustment of P values. P values were adjusted for 54 multiple testing by using FDR correction. The genotypic test was chosen as the genetic test model with lower Akaike information/lower P value. N = 898 PD cases; 921 controls (N = 1,819). CI, confidence interval; Freq., frequency; M, major allele; MAPT, microtubule-associated protein Tau; m, minor allele; OR, odds ratio; SNCA, α-synuclein; SNP, single nucleotide polymorphism.