TABLE 3.

Genotypic association tests of SNCA rs356219 and MAPT rs1800547 SNPs with AAO of Parkinson’s disease with sex, age, and multiple testing adjustments of P values

Gene	SNP	Alleles, M/m	Freq. 11	Freq. 12	Freq. 22	AAO 11, y	AAO 12, y	AAO 22, y	Difference, y	Model	P value	Adjusted P value
SNCA	rs356219	A (1)/G (2)	0.36	0.47	0.17	58.03 ± 0.5	55.84 ± 0.48	55.64 ± 0.85	−1.35 (−2.19 to −0.51)	Log-additive	.0017	.0034
MAPT	rs1800547	A (1)/G (2)	0.56	0.38	0.06	56.46 ± 0.61	56.15 ± 0.75	58.36 ± 1.73	0.30 (−0.66 to 1.26)	Log-additive	.54	.54

Statistically significant P values are bold. Genotypic test calculated in the SNPstats software with sex and age adjustment of P values. The model of inheritance best fitting the data was automatically selected as the model with the lowest Akaike information value. Two SNPs were considered for P value multiple test adjustment. N = 748 PD cases with AAO available. AAO, age at onset; Freq., frequency; M, major allele; MAPT, microtubule-associated protein Tau; m, minor allele; SNCA, α-synuclein; SNP, single nucleotide polymorphism; y, years.