TABLE 5.
SNP rs356219 in SNCA interacts with rs11868112 in RPTOR and rs6456121 in RPS6KA2 in modulating the AAO of idiooathic PD in the International Parkinson’s Disease Genomics Consortium cohort
| Gene | SNP | t statistic CV training | t statistic CV testing | CVC | OR (95% CI) | Association P valuea | Epistatic association P valueb |
|---|---|---|---|---|---|---|---|
| RPTOR | rs11868112 | 5.7190 | 4.2753 | 10/10 | 1.56(1.34–1.81) | 0.001–0.002 | 0.046–0.047 |
| SNCA | rs356219 | ||||||
| RPS6KA2 | rs6456121 | ||||||
Statistically significant P values are bold. Forced Interaction of SNPs rs11868112 in RPTOR, rs356219 in SNCA, and rs6456121 in RPS6KA2 with PD AAO in the International Parkinson’s Disease Genomics Consortium cohort. AAO was considered a continuous variable. N = 2798 PD cases; random seed = 10; CVC = 10. OR was obtained generating a dichotomous dataset comparing early PD AAO (before 60 years) and late PD AAO (after 61 years) based on the average of AAO found with the multifactor dimensionality reduction (60.86 years). AAO, age at onset; CI, confidence interval; CV, cross-validation; CVC, cross-validation count; OR, odds ratio; PD, Parkinson’s disease; SNCA, α-synuclein; SNP, single nucleotide polymorphism.
Normal P value.
P value of explicit test of epistasis obtained with 1000 permutations.