Fig. 5.

Manhattan plot of EWAS of survival (model 2, adjusted for smoking, alcohol consumption and HPV16E6 seropositivity), showing CpG sites within DMRs in red. Each dot represents the EWAS result for a single CpG site, plotting – log₁₀ (P) (y-axis) against the genomic position of the CpG site (x-axis). The horizontal red line is at P < 5.7 × 10⁻⁸ and represents the value below which CpG sites were considered to have good evidence of association with survival