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. 2020 Jun 29;20:600. doi: 10.1186/s12885-020-07007-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Genetic lineage and GM colonization additively determine adenoma numbers in ApcMin mice. a Embryos from the Min/J and Min/D genetic lineages were transplanted into surrogate dams harboring two distinct complex GM profiles; GMJAX and GMHSD. Offspring represent the two genetic lineages which have inherited a GM from their respective surrogate dams (Min/J_GMJAX,n = 13; Min/D_GMJAX,n = 18; Min/J_GMHSD,n = 19; Min/D_GMHSD, n = 10). b Scatter plots comparing mean (± SEM) small intestinal (SI) and colon adenoma counts of the original B6-Apc^Min colony generated at UW McArdle Laboratory (Min/D) to B6-Apc^Min mice acquired from The Jackson Laboratory and maintained at University of Missouri (Min/J) (Min/D, n = 65; Min/J, n = 22). c Scatter plots comparing mean (± SEM) SI and colon adenoma counts of the four rederived groups, including each genetic lineage (Min/J and Min/D) rederived with two complex GMs. *p < 0.05, **p < 0.01, ***P < 0.001; Student’s t-test (a) and Two-way ANOVA with the Student Newman-Keuls method (c)